The United World Antiviral Research Network (UWARN) is an Emerging Infectious Disease Research Center (EIDRC) focused on studying emerging and re-emerging arboviruses. The UWARN partnership brings together worldwide collaborations from investigators in the United States, Brazil, Pakistan, Senegal, South Africa, and Taiwan. UWARN laboratories study emerging and re-emerging high-burden viral arboviruses such as Zika, dengue, and chikungunya. The overarching goal for UWARN research activities is to define the virus/host interactions of arbovirus infection to reveal novel strategies for diagnosis, control, and intervention of infection and disease. Specifically, the UWARN partnership are working on projects focused on investigating the host innate immune responses to arboviruses and developing neutralizing human monoclonal antibodies and de novo engineered arboviral detection protein systems. Together the UWARN research efforts will provide improved understanding of arbovirus disease pathogenesis and pioneer new technologies in diagnostics and therapeutics to improve clinical outcomes in people infected with arboviruses.